Study: Deca Durabolin for Muscle Wasting

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Muscle wasting is common when a patient is immobilized from illness or injury. With the muscles not stimulated by normal activities and load, catabolic (tissue deconstructive) processes dominate. This may result in a significant loss of muscle protein, which is both rapid and pronounced. In some cases this can turn into a serious added complication, interfering with the individual’s recovery and mobility. Over there years, many strategies have been devised and implemented to counter muscle wasting. However, and oddly so in spite of their known tissue building and preserving properties, anabolic steroids are not widely used for this purpose. Studies continue to investigate such applications though, suggesting we may see such medical applications open up again. One such paper was recently published in PlosOne, finding notable benefit with nandrolone decanoate (1).

This paper involves a study on rats. In this case the animals were subject to a procedure called hindlimb unloading, where the back legs are elevated to prevent them from bearing weight. This simulates weightlessness or inactivity in the muscles, which results in atrophy. In this study, one group of rats was also given nandrolone decanoate. This group noticed a significant retention of muscle protein and weight. As such, the group did have the same muscle wasting as those subjected to the procedure and not given the anabolic steroid. As the authors summarized, “…through stimulation of protein synthesis, ND

[nandrolone decanoate] preserves protein content and muscle weight, which may result advantageous to the affected skeletal muscle for functional recovery.” While I suspect that we are far from a day that nandrolone would be considered a standard treatment option for such cases, it is good to see research in this area continue, and felt it good to pass along.

The summary here pertains to the most obvious finding of the study. There is much more to the paper, which is actually an extensive investigation into not only the obvious effects of nandrolone decanoate on muscle disuse atrophy, but also the underlying mechanisms involved. A link to the full article is below for those interested in studying the deeper science of AAS biochemistry and muscle atrophy. It is definitely worth a read.

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(1) Effects of Nandrolone in the Counteraction of Skeletal Muscle Atrophy in a Mouse Model of Muscle Disuse: Molecular Biology and Functional Evaluation. Camerino GM, Desaphy JF, De Bellis M, Capogrosso RF, Cozzoli A, Dinardo MM, Caloiero R, Musaraj K, Fonzino A, Conte E, Jagerschmidt C, Namour F, Liantonio A, De Luca A, Conte Camerino D, Pierno S. PLoS One. 2015 Jun 11;10(6):e0129686. doi: 10.1371/journal.pone.0129686.

By | 2017-04-07T01:10:38+00:00 June 14th, 2015|Categories: Topics: Steroids|Tags: |0 Comments

About the Author:

William Llewellyn is a researcher in the field of human performance enhancement. He is also author of the bestselling ANABOLICS book series, most recently the ANABOLICS 10th Edition. William is an active supporter of the harm reduction community, and currently serves as honorary lecturer at the Centre for Public Health at Liverpool John Moores University.

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